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Cdx2 and muc2 expression were examined in 193 ebd carcinomas, and observed in 37. Objective to report the immunophenotypic expression of p53 and fas expression in various stages in the development of bile duct cancers (intrahepatic and extrahepatic tumor location) and their association with tumor differentiation. Neutrophilic infiltration-related cytokines (interleukin 8, granulocyte colony-stimulating factor g-csf, and granulocyte macrophage colony-stimulating factor gm-csf) were expressed frequently and intensely in carcinoma cells of icc with cirrhosis (40, 80, and 60, respectively) and in icc elements of the combined one (13, 38, and 63, respectively).

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In both cases there was extensive microsatellite instability, with allelic shifts in five of five and four of five microsatellite markers, respectively. We respect the privacy of the users of this site. The finding that alleles of differing lengths were frequently generated between the intraductal and invasive components of those tumors with microsatellite instability suggests that there is significant genetic heterogeneity within these neoplasms.

Genomic dna was extracted from 17 intraductal papillary neoplasms, 6 associated invasive cholangiocarcinomas, and corresponding normal tissues, and microsatellite instability testing was performed using the 5 microsatellite loci recommended by the 1997 national cancer institutesponsored consensus conference (d2s123, d5s346, d17s250, bat-25, and bat-26). Ttf-1 cytoplasmic staining positively correlates with differentiation and the trabecular growth pattern of hcc. Combined hepatocellular-cholangiocarcinoma a histopathologic, immunohistochemical, and in situ hybridization study satish k.

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